Guido Six received his first music lessons in the local community band 'Onder Ons' in his native city of Wervik before joining the Academy of Music in Menin where he won the Medal of the Government in clarinet performance. In 1973 he attended the Royal Conservatory of Music in Ghent where he obtained First Prizes in music theory, transposition, clarinet, chamber music, harmony and counterpoint and also the Higher Diploma in clarinet performance and the Master Degree in chamber music.
He joined the band of the National Police as principal clarinet at the age of 18. In 1976, he started teaching at the Academies of Music in Menin, Waregem and Furnes. In 1983 he left the Police Band to become a fulltime clarinet and ensemble teacher at the Academy in Furnes and at the Conservatory at Sea in Ostend. In 1985 he joined the faculty of the pedagogy department of the Royal Conservatory in Ghent where he taught clarinet pedagogy and literature.
He was the director of the Conservatory at Sea in Ostend since July 1994. He was also the conductor of the Clarinet Choir Claribel.
Guido Six and his son Jef died in a tragic road accident in October 2015.